Ekaform · v0 · Private alpha

The operating system
for computational science.
Scientific knowledge,
made executable.
Turn papers into
predictive systems.
From literature to
living models.

Ekaform extracts equations from scientific literature, connects them into a calibrated knowledge graph, and compiles them into executable, reproducible simulations. Terraform did it for cloud infrastructure. We do it for science.

$ ekaform compile paper.pdf --calibrate data.csv

Built for the next generation of AI-native science.

01 / Architecture

From papers to predictions.

Six stages. One compiler for scientific knowledge. Each step is auditable, reproducible, and traceable back to its source.

  1. 01

    Papers

    Ingest open-access literature, technical reports, or your internal corpus.

  2. 02

    Extract

    Parse equations, parameters, and symbolic structures from raw documents.

  3. 03

    Graph

    Connect variables, assumptions, and physical relationships into a typed knowledge graph.

  4. 04

    Calibrate

    Optimize parameters against real observations through differentiable data assimilation.

  5. 05

    Simulate

    Run differentiable, reproducible simulations from the compiled scientific graph.

  6. 06

    Predict

    Deploy as an API, embed in agents, or version it like any other production system.

02 / Capabilities

A compiler for the things scientists actually do.

A

Equation extraction

Parse equations and symbolic structures directly from scientific literature — typed, unit-aware, and traced back to source.

B

Scientific knowledge graphs

Connect models, variables, parameters, and physical relationships into a queryable, versioned graph.

C

Data assimilation

Calibrate the graph against your experimental data. Bayesian inference, gradient descent, and uncertainty bounds — built in.

D

Executable simulations

Compile to a differentiable runtime. Run on CPU, GPU, or distributed clusters — same code, same results.

E

Reusable scientific systems

Composable libraries of executable scientific knowledge. Import a model the way you import a package.

F

Provenance & audit

Every parameter traces back to the paper, equation, and dataset that produced it. Built for regulated science.

03 / Manifesto

Science was written for humans.
We make it executable.

Fifty million scientific papers contain the equations to simulate molecules, climates, markets, and materials. They sit, unstructured, inside PDFs.

Every team that needs a model rebuilds it from scratch — re-deriving equations, re-coding solvers, re-calibrating parameters someone else has already published. The cost of that reconstruction is measured in years, careers, and entire research programs.

Ekaform converts scientific knowledge into machine-readable, executable infrastructure — a programmable substrate for the AI era.

04 / Use cases

Where Ekaform is being deployed.

Pharma · Biotech

Drug discovery & toxicity

Predict PK/PD, toxicity windows, and translational outcomes from literature plus your preclinical data.

Read more
Climate · Earth

Climate & earth systems

Compose differentiable atmospheric, oceanic, and ecological models from the published canon.

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Materials

Materials modeling

Predict stability, degradation, and structure-property relationships from the literature you already cite.

Read more
Finance · Economics

Economic forecasting

Compose macro and micro models with provenance — every coefficient traceable to its source paper.

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AI · Agents

Autonomous scientific agents

Give your agents access to executable scientific knowledge — not just text.

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Defense · Aerospace

Defense & aerospace modeling

Sovereign, on-premise scientific simulation built from your own classified corpus.

Read more
05 / Developers

Programmable science.

Ekaform exposes scientific models as first-class software primitives. Import, compose, calibrate, and simulate — from a single SDK.

  • Python, TypeScript, and Rust bindings
  • Differentiable runtime — gradients, Jacobians, sensitivities
  • Versioned models with full provenance
  • On-prem, air-gapped, or cloud deployment
pk_pd_translation.py
# compose a model directly from the published literature
from ekaform import load, calibrate

model = load("pk_pd/translation/v4")

# calibrate against your preclinical observations
model.calibrate(
    data="./preclinical/mouse_cohort_2025.csv",
    method="variational",
)

# run a calibrated simulation
prediction = model.simulate(
    dose=12.5,
    subject="human/adult/f",
    horizon_hours=72,
)

prediction.trace()  # → equations, papers, parameters, uncertainty

The future of science is executable.

Ekaform is in private alpha with a small group of research and infrastructure partners. If you're working on AI-native science, we want to hear from you.

team@ekaform.com · UC Berkeley alumni · Currently in stealth